Patients with Advanced Pancreatic Cancer when Treated with Metformin Showed Increased Survival Rates

Patients with Advanced Pancreatic Cancer when Treated with Metformin Showed Increased Survival Rates

Positive Overall Survival Rate in Patients With Advanced Pancreatic Cancer Treated On Metformin For Diabetes Mellitus Introduction Pancreatic cancer (PC) is the fourth common cause of cancer death in both Asian and western countries. At the time of diagnosis, only 10%-20% of patients are eligible for curative surgery. PC is an aggressive malignancy with a 5-year survival rate of < 5%. Diabetes mellitus (DM) is linked as a risk factor in a...   Read more


Mesalamine Granules lowers the risk of Relapse and Side Effects in Corticosteroid-Induced Ulcerative Colitis

Use of Mesalamine Granules Results in Low risk of Relapse and Side Effects in Patients Who Achieved Corticosteroid-Induced Ulcerative Colitis Remission Abstract Background Corticosteroids are used in the treatment of ulcerative colitis (UC). Patients who discontinues the treatment or tapers it has remission period. To avoid the corticosteroid remission, alternative treatments limiting steroid exposure and UC relapse would be beneficial. It ...   Read more


Postoperative Peristomal Adhesions decreased by the use of Sodium Hyaluronate Gel and Chitosan

Sodium Hyaluronate Gel and Chitosan are Effective in Preventing Postoperative Peristomal Adhesions after Defunctioning Enterostomy Abstract Peristomal adhesions complicate closure of defunctioning enterostomy. The efficacy and safety of sodium hyaluronate gel and chitosan in preventing postoperative adhesion have not been extensively studied. This study aims to evaluate the safety and efficacy of sodium hyaluronate gel and chitosan in the pr...   Read more


Reverse Hybrid Therapy is Effective As The First Line Therapy For Helicobacter Pylori Infection

Reverse hybrid Therapy Replaced Standard Triple Therapy as The First Line Therapy For Helicobacter Pylori Infection Background Information Reverse hybrid therapy is a single-step double-phase treatment for Helicobacter pylori (H. pylori) infection with less cost than standard triple therapy. We conducted a randomized, controlled study to compare the efficacies of standard triple therapy and reverse hybrid therapy in the treatment of H. pylor...   Read more


Ramosetron Reduces Symptoms of Irritable Bowel Syndrome and Improves Quality of Life in Women

Ramosetron Reduces Symptoms of Irritable Bowel Syndrome and Improves Quality of Life in Women Background Information Irritable bowel syndrome (IBS) is a common disorder of the gastrointestinal system. It is classified into for types like IBS with diarrhea (IBS-D), IBS with constipation, mixed-type IBS, and unsubtyped IBS. Many agents like 5-hydroxytryptaminereceptor 3 (5-HT3) antagonists were developed for treating IBS-D. Alosetron has be...   Read more


Low-dose Budosenide Helps in Maintenance of Clinical Remission in Collagenous Colitis

Low-dose Budosenide Helps in Maintenance of Clinical Remission in Collagenous Colitis OBJECTIVE: To assess low-dose budesonide therapy on the maintenance of clinical remission, in patients with collagenous colitis. DESIGN: A prospective, randomised, placebo-controlled study beginning with an 8-week open-label induction phase in which patients with histologically confirmed active collagenous colitis received budesonide (Budenofalk, 9 mg/day...   Read more


Drotaverine Hydrochloride is effective and safe in Children with Recurrent Abdominal Pain

Efficacy and Safety of Drotaverine Hydrochloride in Children with Recurrent Abdominal Pain: A Randomized Placebo Controlled Trial Objective: To evaluate the efficacy and safety of Drotaverine hydrochroride in children with recurrent abdominal pain. Design: Double blind, randomized placebo-controlled trial. Setting: Pediatric Gastroenterology clinic of a teaching hospital. Participants: 132 children (age 4-12 years) with recurrent abdo...   Read more


CORE II- Budesonide Multi-Matrix is the Best Possible Treatment for Remission of Ulcerative Colitis

Budesonide Multi-Matrix is the Best Possible Treatment for Remission of Ulcerative Colitis Background information Ulcerative colitis (UC) is a chronic idiopathic inflammatory disorder involving the colonic mucosa and is characterized by periods of active symptomatic disease interspersed with periods of clinical remission. The 5-aminosalicylates are the first line therapy for the induction of remission in patients with mild-to-moderate UC. Co...   Read more


Combo of Tenofovir Disoproxil Fumarate and Peginterferon α-2a Increases Loss of HBsAG in Hepatitis B

Combo of Tenofovir Disoproxil Fumarate and Peginterferon α- 2a Increases Loss of Hepatitis B Surface Antigen in Chronic Hepatitis B BACKGROUND & AIMS Patients chronically infected with the hepatitis B virus rarely achieve loss of serum hepatitis B surface antigen (HBsAg) with the standard of care. In the study it was evaluated, HBsAg loss in patients receiving the combination of tenofovir disoproxil fumarate (TDF) and peginterferon a-2a...   Read more


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