Levetiracetam is More Effective than Carbamazepine and Lamotrigine in Newly Diagnosed Focal Epilepsy

Levetiracetam is More Effective than Carbamazepine and Lamotrigine in Newly Diagnosed Focal Epilepsy

Levetiracetam is More Effective than Carbamazepine and Lamotrigine in Newly Diagnosed Focal Epilepsy Background Information The elderly represent the most rapidly growing age group within the global population, and this demographic group also has the highest incidence of epilepsy. Half of all newly occurring epileptic seizures are expected to occur in patients aged 60 and older. Anti-epileptic drugs are used by 2% of community-dwelled and...   Read more


Levetiracetam Helps Treat Epileptic Seizures After Liver Transplantation

Treatment of Epileptic Seizures after Liver Transplantation by Levetiracetam Introduction Seizures may be caused due to neurotoxicity induced by sepsis, metabolic encephalopathy, immunosuppressant medications, central nervous system infections, and cerebrovascular complications. It occurs 6% to 8% in the patients who had undergone liver transplantation. Levetiracetam (LEV) is a new generation anti-epileptic drug. It is excreted in unchang...   Read more


Establishing pathological cut-offs of brain atrophy rates in multiple sclerosis

Establishing Pathological Cut-offs of Brain Atrophy Rates in multiple sclerosis BACKGROUND In Multiple sclerosis (MS) the pathological hallmark is the focal demyelination of cerebral white matter. There will also be a significant brain atrophy throughout the MS course, These are the volumetric changes occurring in MS have been correlated with the physical disability and cognitive impairment, and is also useful for understanding the pathophys...   Read more


Delayed-release dimethyl fumarate (DMF) effective in relapsing-remitting multiple sclerosis (RRMS)

Delayed-Release Dimethyl Fumarate (DMF) is used to treat Relapsing-Remitting Multiple Sclerosis (RRMS) Background information In the early stages of multiple sclerosis (MS), autoreactive lymphocytes gain access to the central nervous system, initiating a cascade of events leading to demethylation, axonal transaction, and neurodegeneration. Therefore, the disease should be treated at the early stages. Inflammation and neurodegenerative proces...   Read more


Adjunctive Therapy of Lacosamide with Anti-epileptic Drugs Reduces the Seizure Frequency

Adjunctive Therapy of Lacosamide with Anti-epileptic Drugs Reduces the Seizure Frequency Background Information More that 50% of the patients may require a change in the antiepileptic drug regimen to reduce the seizure frequency. The changes may include shifting to monotherapy regimens or antiepileptic drug polytherapy. The goal of the anti-epileptic drug is seizure freedom. Lacosamide works by enhancing the sodium-channel slow inactivati...   Read more


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