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Rosuvastatin Improves Arterial Stiffness and Blood Pressure in Case of Inflammatory Joint Disease

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Long-Term Rosuvastatin Treatment Improves Arterial Stiffness and Blood Pressure in Patients with Inflammatory Joint Disease

Background Information

High blood pressure is a common disease in patients with inflammatory joint disease (IJD). It is related with the presence of subclinical atherosclerosis and arterial stiffness.

The augmentation index (Alx) and the aortic pulse wave velocity (Apwv) are the measures of arterial stiffness that predict cardiovascular disease in general population.

Aim of the Study

The aim of the study is to analyze the effect of long-term use of rosuvastatin therapy on arterial stiffness, aortic pulse wave velocity and blood pressure in patients with inflammatory joint disease along with atherosclerosis.

Study Criteria

The study included all the men and women who were diagnosed with inflammatory joint disease. Patients with asymptomatic cholesterol plaques demonstrated in carotid artery by ultrasound imaging were also included in the study.

The study excluded the patients on concomitant statin therapy and who are contraindicated to statin therapy. People with secondary hyperlipidemia and other diseases that would interfere with the study were also excluded.

Study Protocol

Rosuv4The linear regression of both adjusted and unadjusted analysis was applied to evaluate the correlation between arterial stiffness and blood pressure levels. The analysis software used for the study is SPSS Version 21. The results were analyzed using Analysis of variance (ANOVA), Chi-square test, linear regression analysis.

Results

Reduction in the systolic and diastolic blood pressure after the 18 months of rosuvastatin therapy

Rosuv1There was a significant reduction in the systolic and diastolic blood pressure in the patients with inflammatory joint disease after the 18 months therapy with rosuvastatin.

Reduction in the Augmentation index (∆Alx) after the 18 months of therapy

Rosuv2The Augmentation index (∆Alx) which measures the arterial stiffness is found to be reduced after the 18 months of rosuvastatin therapy. This shows that the risk of arterial stiffness is reduced with the long-term therapy.

Change in aortic pulse wave velocity (aPWV)

Rosuv3The aortic pulse wave velocity which is used to measure the arterial stiffness is reduced. This indicates the reduction in the risk of arterial stiffness.

Conclusion

From the results obtained through the study, the long-term use of lipid lowering agents decreases the risk of cardiovascular disease in the patients with inflammatory joint disease.

The study provides the evidence that long-term therapy of rosuvastatin lowers the blood pressure and reduces the risk of arterial stiffness.

Reference

Eirik Ikdahl, et al Sustained Improvement of Arterial Stiffness and Blood Pressure after Long-Term Rosuvastatin Treatment in Patients with Inflammatory Joint Diseases: Results from the RORA-AS Study. PLoS One. 2016 Apr 19; 11(4):e0153440.

Available at: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153440/

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