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Sertaconazole 2% Cream Is Effective Compared To Metronidazole 1% Gel In Seborrheic Dermatitis

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What's This?

Sertaconazole 2% Cream is Effective Compared to Metronidazole 1% Gel in the Treatment of Seborrheic Dermatitis

Background Information

Seborrheic dermatitis (SD) is an inflammatory skin condition that often affects the scalp, face, and neck. It cannot be cured but quickly responds to the proper treatment. The treatment usually involves topical corticosteroids and anti-fungal drugs. Sertaconazole is a class of medications called imidazoles. It works by slowing the growth of fungi that cause infection.

Aim of the Study

The aim of this study was to compare the efficacy of sertaconazole 2% cream vs. metronidazole 1% gel in the treatment of seborrheic dermatitis.

Study Method

A total of 156 subjects who were suffering from SD were included in the study. The subjects were randomly divided into two groups – Sertaconazole group and Metronidazole group. The subjects in the sertaconazole group received local sertaconazole 2% cream twice daily for four weeks. The subjects in the metronidazole group received metronidazole 1% gel twice a day for four weeks. The subjects in both the groups were examined by dermatologist for the improvement of the clinical symptoms.

Statistical analysis

All statistical analysis was performed with SPSS 16 software. The coupled T test and non-parametric test (Wilcoxon) were used to compare pre-treatment and post-treatment results. The variance analysis test, for repeated measurements, was used for data analysis. Kappa agreed coefficients and the Chi-square test were used to determine satisfaction rate.

The final recovery rate was calculated based on the pre-treatment and post-treatment clinical findings. The study was continued for 28 days and the final visit was conducted on the 28th day of the study.

Study Results

The frequency distribution of the patient satisfaction values after the consumption of the drugs after 14 and 28 days were observed. Twenty-eight days after metronidazole 1% gel consumption, the satisfaction level was about 56.4%. The highest level of satisfaction (87.1%) was observed 28 days after sertaconazole 2% cream consumption.

Patient satisfaction on the 14th day of the study

Patient satisfaction on the 28th day of the study

Conclusion

Sertaconazole was not found to be associated with any serious adverse events in our study. These results suggest that sertaconazole 2% cream is a well tolerated and effective treatment for seborrheic dermatitis.

Reference

Goldust M et al, A double blind study of the effectiveness of sertaconazole 2% cream vs. metronidazole 1% gel in the treatment of seborrheic dermatitis. Ann Parasitol. 2013; 59(4):173-7.

Available at: http://www.ncbi.nlm.nih.gov/pubmed/24791343/

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