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Vitamin D Decreases Painful Diabetic Neuropathy

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Vitamin D Decreases Painful Diabetic Neuropathy

Background

Painful diabetic neuropathy is the pain caused due to damage of nerves which leads to numbness and weakness in the arms, feet, and legs. It has been recently observed in patients with type 2 diabetes with painful symptoms. It is characterized by symmetrically lower limb paresthesia, dyesthesiae, lancinating pains and allodynia, with nocturnal exacerbation and significant sleep disturbance, with a reduced quality of life.

Aim and Objective of study

The main objective of the study is to evaluate the effect of high dose of vitamin D in patients with painful diabetic neuropathy.

Study Method

Inclusion Criteria

The patients of age 18-80 years with type 1 or type 2 diabetes and with glycated hemoglobin (HbA1c) level 11 % at the screening visit are considered to be eligible for the study.

Exclusion Criteria

Patients with the following conditions are excluded from the study.

  • Renal impairment
  • HIV infection
  • Allergy to any nut products
  • Taking vitamin D supplement
  • Pregnant and breast feeding female patients
  • History of primary and tertiary hypothyroidism

Assessment

The patients who are suffering with painful diabetic neuropathy are selected for the four subsequent visits for every 5 ±1 week such that the first, second, third, fourth, and fifth visits occurred at 4-6; 8-12; 14-16; 18-20 weeks respectively.

A single dose of intramuscular dose of 6, 00,000 IU of vitamin D was administrated during the first visit (visit 1).

Statistical Analysis

Analysis of variance and paired Student t test were used depending on the normality of the data. Regression analyses were under taken between baseline status and total McGill pain location, McGill pain score, DNA, and positive symptoms at baseline.

Results

Pain measurement from pre-treatment baseline to the final visit

It represents the measurement of pain from pre-treatment baseline to the final visit. It shows the significant decrease in the pain and positive symptoms from the visit 2 to the final visit.

Pre-treatment baseline of vitamin D Vs Final visit (V5) (McGill pain score medium)
 

The status of vitamin D at a dose of <30 ng/mL and ≥30 ng/mL showed a significant decrease in the pain during the final visit.

Pre-treatment baseline of vitamin D Vs Final visit (V5) (Positive Symptoms Medium)
 

The status of vitamin D at a dose of <30 ng/mL and ≥30 ng/mL showed a significant decrease in the pain during the final visit.

Conclusion

When the patients with painful diabetic neuropathy are treated with single intramuscular dose of 600000 IU (international unit) of vitamin D there is significant decrease in the pain. It is safe and efficacious for the treating painful diabetic neuropathy.

Reference:

Abdul, B et al. Vitamin D for the treatment of painful Diabetic Neuropathy. BMJ Open Diabetes Res Care. 2016; 4(1).

Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800070/

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